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thankathinkal hindi mp3 songThere is a tremendous need to find new approaches to treat autoimmune inflammatory disorders, including those that result in joint damage, kidney disease, and neurological disease. It is important to realize that on a global basis, autoimmune disorders are the most common group of chronic diseases, affecting approximately 50 million people. Many of these diseases are characterized by the presence of T cells and B cells. In vitro, T cells are necessary and sufficient for the induction of autoimmune-like diseases. Autoimmune phenomena in animal models are often induced by depleting T cells or cytokines, such as IL-4, IL-7, IL-15, or IL-17.
Generally, autoimmune diseases are characterized by an overactive immune response against the self. The underlying cause of autoimmune diseases remains elusive. While the immune response is often directed against antigens present only in small amounts in the body, with normal hosts, the immune response never causes functional damage. Typically, these diseases are actually the result of a long-term disorder in immune regulation.
There are five major types of human autoimmune diseases, which include:
1. Systemic lupus erythematosus (SLE) (also called systemic autoimmune disease) affects multiple organ systems and is characterized by the presence of autoantibodies and immunological abnormalities. SLE is the prototypical disease of systemic autoimmune. The pathogenesis of SLE is not fully understood, but it is thought that an imbalance of T helper cell 1 (Th1) and Th2 cytokines, resulting in altered immune complex processing by the lymph node, plays a central role in this disease. SLE has a characteristic pattern of autoantibodies (antinuclear
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